Proton Pump Inhibitors such as Prilosec, Nexium, Prevacid, Protonix, Acipex, Dexilient, and Kapidex may increase the risk of chronic kidney failure. If you or a loved one suffered kidney failure or have been diagnosed with chronic kidney disease after daily use of the prescription strength Prilosec or Nexium, or over the counter Prilosec or Nexium (Brand name only) you may be eligible for compensation.
Proton Pump Inhibitors work by blocking acid release into the stomach. They are used to treat gastroesophageal reflux disease (GERD) which may occur in up to 60 percent of the adult population each year. They are also used to treat peptic ulcer disease (PUD) and a number of other stomach conditions such as “heartburn”.
The PPI market is said to be worth upwards of $10 billion annually in the U.S. alone and Nexium (esomeprazole) was the best selling prescription medication in 2012 and number two on the same list in 2013 with annual revenue of nearly $6 billion.
Up to 14 percent of U.S. adults have received prescription PPI medications and all three of the most popular PPIs are now available over-the-counter. Some estimates show that at least 25% of long-term PPI users could discontinue the medications with no adverse events and that many had started taking them with no clear indication.
The report in the February 2016 issue of JAMA was the result of an observational study which compared CKD rates of patients who were taking PPI medications over different periods of time. The study involved the examination of medical records of 10,482 patients whose average medical follow-up was 13.9 years. The longer patients had taken PPI medications, the more likely they were to develop chronic kidney disease with an estimated increase risk of 20 to 50 percent. PPI use had already been shown to increase the risk of acute kidney events in patients with prior kidney damage but the recent study excluded patients with pre-existing renal compromise.
Long-term use of PPI medications may cause problems with the body’s ability to absorb calcium, magnesium and other vital nutrients. Patients who take the drugs for an extended period of time (typically over one year) are at risk of suffering kidney damage, bone fractures / breaks and other serious side effects.